APPLICATIONS AND CHALLENGES IN DESIGNING VHH-BASED BISPECIFIC ANTIBODIES: LEVERAGING MACHINE LEARNING SOLUTIONS

Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions

The development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties LC and biophysical characteristics to produce a drug-like therapeutic.These building blocks play an important role in the overall quality of the molecule and can influence many impo

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Investigating matrix interference in the pharmacopeial limit test for aluminum in citric acid: a re-examination, for revision of the method

In many pharmacopoeias, the limit test used for determining the level of aluminum in citric acid labeled for use in the manufacture of dialysate, is based on solvent extraction using 8-hydroxyquinoline and measurement of fluorescence.However, the fluorescence intensity (F.I.) readout from the extract of citric acid samples has been found to Wood Ch

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Type 2 Diabetes Contributes to Altered Adaptive Immune Responses and Vascular Inflammation in Patients With SARS-CoV-2 Infection

SARS-CoV-2, which initially emerged in November of 2019, wreaked havoc across the globe by leading to clinical acute respiratory distress syndrome and continues to evade current therapies Bushing today due to mutating strains.Diabetes mellitus is considered an important risk factor for progression to severe COVID disease and death, therefore additi

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